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Science 29 October 1982:
Vol. 218. no. 4571, pp. 469 - 471
DOI: 10.1126/science.7123244
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Articles

Science, Vol 218, Issue 4571, 469-471
Copyright © 1982 by American Association for the Advancement of Science

articles

Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations

RS Beach, ME Gershwin, and LS Hurley

Pregnant Swiss Webster mice were fed a diet moderately deficient in zinc from day 7 of gestation until parturition. Offspring of these mice showed depressed immune function through 6 months of age. In addition, the second and third filial generations, all of which were fed only the normal control diet, continued to manifest reduced immunocompetence, although not to the same degree as in the first generation.


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Zinc Supplementation of Pregnant Rats with Adequate Zinc Nutriture Suppresses Immune Functions in Their Offspring.
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J. Nutr. 137, 1037-1042
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Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men.
H. Ghattas, D. L Wallace, J. A Solon, S. M Henson, Y. Zhang, P. T Ngom, R. Aspinall, G. Morgan, G. E Griffin, A. M Prentice, et al. (2007)
Am. J. Clinical Nutrition 85, 480-487
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Diet and the developing immune system.
S C Langley-Evans and L J Carrington (2006)
Lupus 15, 746-752
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Developmental Consequences of Trace Mineral Deficiencies in Rodents: Acute and Long-Term Effects.
C. L. Keen, L. A. Hanna, L. Lanoue, J. Y. Uriu-Adams, R. B. Rucker, and M. S. Clegg (2003)
J. Nutr. 133, 1477S-1480
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The Plausibility of Micronutrient Deficiencies Being a Significant Contributing Factor to the Occurrence of Pregnancy Complications.
C. L. Keen, M. S. Clegg, L. A. Hanna, L. Lanoue, J. M. Rogers, G. P. Daston, P. Oteiza, and J. Y. Uriu-Adams (2003)
J. Nutr. 133, 1597S-1605
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Micronutrients and vertical transmission of HIV-1.
M. L Dreyfuss and W. W Fawzi (2002)
Am. J. Clinical Nutrition 75, 959-970
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Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival.
R. K. Chandra (1996)
PNAS 93, 14304-14307
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Zinc Deficiency and Immune Function.
P. J. Fraker, P. Jardieu, and J. Cook (1987)
Arch Dermatol 123, 1699-1701
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Zinc and Cutaneous Inflammation.
D. Norris (1985)
Arch Dermatol 121, 985-989
   Abstract »    PDF »
Altered Development of Immunocompetence Following Prenatal or Combined Prenatal-Postnatal Insult: A Timely Review.
R. R. Schmidt (1984)
International Journal of Toxicology 3, 57-72
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Nutrition and the Acquired Immunodeficiency Syndrome.
R. S. BEACH and P. F. LAURA (1983)
Ann Intern Med 99, 565-566
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