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Science 22 October 1982:
Vol. 218. no. 4570, pp. 391 - 394
DOI: 10.1126/science.7123240
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Articles

Science, Vol 218, Issue 4570, 391-394
Copyright © 1982 by American Association for the Advancement of Science

articles

Hemispheric asymmetries in the behavioral and hormonal effects of sexually differentiating mammalian brain

EJ Nordeen and P Yahr

Estrogen pellets were placed in either the right or left hypothalamus of newborn female rats so that only one side of this brain area was exposed to the postnatal masculinizing and defeminizing effects of the hormone. The effects of estrogen on gonadotropin secretion and reproductive behavior depended on both the region and the side of implantation. Exposure of the left hypothalamus to estrogen resulted in defeminized development. Exposure of the right hypothalamus to estrogen resulted in masculinized development. Thus the response of the developing hypothalamus to gonadal steroids may be asymmetric.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reproductive Endocrine Disorders in Women With Partial Seizures of Temporal Lobe Origin.
A. G. Herzog, M. M. Seibel, D. L. Schomer, J. L. Vaitukaitis, and N. Geschwind (1986)
Arch Neurol 43, 341-346
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Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: III. A Hypothesis and a Program for Research.
N. Geschwind and A. M. Galaburda (1985)
Arch Neurol 42, 634-654
   Abstract »    PDF »
Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: II. A Hypothesis and a Program for Research.
N. Geschwind and A. M. Galaburda (1985)
Arch Neurol 42, 521-552
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