Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Nanomedicine Summit 2008

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 October 1982:
Vol. 218. no. 4570, pp. 381 - 384
DOI: 10.1126/science.6289440
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4570, 381-384
Copyright © 1982 by American Association for the Advancement of Science

articles

Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli

RJ Watson, JH Weis, JS Salstrom, and LW Enquist

The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid enabled synthesis in Escherichia coli of an immunoreactive gD-related polypeptide. The potential of this system for preparation of a type-common herpes simplex virus vaccine is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pseudorabies Virus Glycoprotein gD Contains a Functional Endocytosis Motif That Acts in Concert with an Endocytosis Motif in gB To Drive Internalization of Antibody-Antigen Complexes from the Surface of Infected Monocytes.
J. Ficinska, G. Van Minnebruggen, H. J. Nauwynck, K. Bienkowska-Szewczyk, and H. W. Favoreel (2005)
J. Virol. 79, 7248-7254
   Abstract »    Full Text »    PDF »
Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion.
A. Zago, C. R. Jogger, and P. G. Spear (2004)
PNAS 101, 17498-17503
   Abstract »    Full Text »    PDF »
Downstream Sequences Influence the Choice between a Naturally Occurring Noncanonical and Closely Positioned Upstream Canonical Heptameric Fusion Motif during Bovine Coronavirus Subgenomic mRNA Synthesis.
A. Ozdarendeli, S. Ku, S. Rochat, G. D. Williams, S. D. Senanayake, and D. A. Brian (2001)
J. Virol. 75, 7362-7374
   Abstract »    Full Text »    PDF »
Detection of Herpes Simplex Virus DNA by Real-Time PCR.
H. H. Kessler, G. Mühlbauer, B. Rinner, E. Stelzl, A. Berger, H.-W. Dörr, B. Santner, E. Marth, and H. Rabenau (2000)
J. Clin. Microbiol. 38, 2638-2642
   Abstract »    Full Text »
Description of a Nonlethal Herpes Simplex Virus Type 1 Glycoprotein D Deletion Mutant Affecting a Site Frequently Used for PCR.
P. V. Coyle, S. Jain, D. Wyatt, C. McCaughey, and H. J. O'Neill (2000)
Clin. Vaccine Immunol. 7, 322-324
   Abstract »    Full Text »    PDF »
Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM.
A. V. Nicola, M. Ponce de Leon, R. Xu, W. Hou, J. C. Whitbeck, C. Krummenacher, R. I. Montgomery, P. G. Spear, R. J. Eisenberg, and G. H. Cohen (1998)
J. Virol. 72, 3595-3601
   Abstract »    Full Text »    PDF »
Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms.
C. R. Brunetti, K. S. Dingwell, C. Wale, F. L. Graham, and D. C. Johnson (1998)
J. Virol. 72, 3330-3339
   Abstract »    Full Text »    PDF »
The Glycoprotein D (US6) Homolog Is Not Essential for Oncogenicity or Horizontal Transmission of Marek's Disease Virus.
A. S. Anderson, M. S. Parcells, and R. W. Morgan (1998)
J. Virol. 72, 2548-2553
   Abstract »    Full Text »    PDF »
Glycoproteins gB, gD, and gHgL of Herpes Simplex Virus Type 1 Are Necessary and Sufficient To Mediate Membrane Fusion in a Cos Cell Transfection System.
A. Turner, B. Bruun, T. Minson, and H. Browne (1998)
J. Virol. 72, 873-875
   Abstract »    Full Text »    PDF »
Rapid identification of nonessential genes of herpes simplex virus type 1 by Tn5 mutagenesis.
P. Weber, M Levine, and J. Glorioso (1987)
Science 236, 576-579
   Abstract »    PDF »
Recombinant vaccinia virus: immunization against multiple pathogens.
M. Perkus, A Piccini, B. Lipinskas, and E Paoletti (1985)
Science 229, 981-984
   Abstract »    PDF »
Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice.
K. Cremer, M Mackett, C Wohlenberg, A. Notkins, and B Moss (1985)
Science 228, 737-740
   Abstract »    PDF »
Protection from genital herpes simplex virus type 2 infection by vaccination with cloned type 1 glycoprotein D.
P. Berman, T Gregory, D Crase, and L. Lasky (1985)
Science 227, 1490-1492
   Abstract »    PDF »
Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D.
P. Berman, D Dowbenko, L. Lasky, and C. Simonsen (1983)
Science 222, 524-527
   Abstract »    PDF »
Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line.
J. Seigneurin, C Desgranges, D Seigneurin, J Paire, J. Renversez, B Jacquemont, and C Micouin (1983)
Science 221, 173-175
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)