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Science 22 October 1982:
Vol. 218. no. 4570, pp. 341 - 347
DOI: 10.1126/science.6289435
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Articles

Science, Vol 218, Issue 4570, 341-347
Copyright © 1982 by American Association for the Advancement of Science

articles

Transposition of cloned P elements into Drosophila germ line chromosomes

AC Spradling and GM Rubin

Recombinant DNA carrying the 3-kilobase transposable element was injected into Drosophila embryos of a strain that lacked such elements. Under optimum conditions, half of the surviving embryos showed evidence of P element-induced mutations in a fraction of their progeny. Direct analysis of the DNA of strains derived from such flies showed them to contain from one to five intact 3-kilobase P elements located at a wide variety of chromosomal sites. DNA sequences located outside the P element on the injected DNA were not transferred. Thus P elements can efficiently and selectively transpose from extrachromosomal DNA to the DNA of germ line chromosomes in Drosophila embryos. These observations provide the basis for efficient DNA-mediated gene transfer in Drosophila.


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   Abstract »    Full Text »    PDF »
Two Functionally Identical Modular Enhancers in Drosophila Troponin T Gene Establish the Correct Protein Levels in Different Muscle Types.
J.-A. Mas, E. Garcia-Zaragoza, and M. Cervera (2004)
Mol. Biol. Cell 15, 1931-1945
   Abstract »    Full Text »    PDF »
Transcription of Drosophila Troponin I Gene Is Regulated by Two Conserved, Functionally Identical, Synergistic Elements.
M.-C. Marin, J.-R. Rodriguez, and A. Ferrus (2004)
Mol. Biol. Cell 15, 1185-1196
   Abstract »    Full Text »    PDF »
Drosophila Su(Hw) Regulates an Evolutionarily Conserved Silencer from the Mouse H19 Imprinting Control Region.
S. SCHOENFELDER and R. PARO (2004)
Cold Spring Harb Symp Quant Biol 69, 47-54
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Pleiotropic Effect of Disrupting a Conserved Sequence Involved in a Long-Range Compensatory Interaction in the Drosophila Adh Gene.
J. F. Baines, J. Parsch, and W. Stephan (2004)
Genetics 166, 237-242
   Abstract »    Full Text »    PDF »
echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway.
A. Ahmed, S. Chandra, M. Magarinos, and H. Vaessin (2003)
Development 130, 6295-6304
   Abstract »    Full Text »    PDF »
Genetics of P-Element Transposition Into Drosophila melanogaster Centric Heterochromatin.
A. Y. Konev, C. M. Yan, D. Acevedo, C. Kennedy, E. Ward, A. Lim, S. Tickoo, and G. H. Karpen (2003)
Genetics 165, 2039-2053
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Genetic mosaic techniques for studying Drosophila development.
S. S. Blair (2003)
Development 130, 5065-5072
   Abstract »    Full Text »    PDF »
Targeted Mutation of a Drosophila Odor Receptor Defines Receptor Requirement in a Novel Class of Sensillum.
T. Elmore, R. Ignell, J. R. Carlson, and D. P. Smith (2003)
J. Neurosci. 23, 9906-9912
   Abstract »    Full Text »    PDF »


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