Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 October 1982:
Vol. 218. no. 4569, pp. 297 - 298
DOI: 10.1126/science.6289434
Prev | Table of Contents

Articles

Science, Vol 218, Issue 4569, 297-298
Copyright © 1982 by American Association for the Advancement of Science

articles

An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system

D Feldman, Y Do, A Burshell, P Stathis, and DS Loose

A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals.
J. A. McLachlan (2001)
Endocr. Rev. 22, 319-341
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae produces a yeast substance that exhibits estrogenic activity in mammalian systems.
D Feldman, P. Stathis, M. Hirst, E. Stover, and Y. Do (1984)
Science 224, 1109-1111
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)