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Science 15 October 1982:
Vol. 218. no. 4569, pp. 297 - 298
DOI: 10.1126/science.6289434
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Articles

Science, Vol 218, Issue 4569, 297-298
Copyright © 1982 by American Association for the Advancement of Science

articles

An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system

D Feldman, Y Do, A Burshell, P Stathis, and DS Loose

A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals.
J. A. McLachlan (2001)
Endocr. Rev. 22, 319-341
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae produces a yeast substance that exhibits estrogenic activity in mammalian systems.
D Feldman, P. Stathis, M. Hirst, E. Stover, and Y. Do (1984)
Science 224, 1109-1111
   Abstract »    PDF »


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