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Science 15 October 1982:
Vol. 218. no. 4569, pp. 293 - 295
DOI: 10.1126/science.6181563
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Articles

Science, Vol 218, Issue 4569, 293-295
Copyright © 1982 by American Association for the Advancement of Science

articles

Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer

HM Jensen, I Chen, MR DeVault, and AE Lewis

Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.


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