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Science 15 October 1982:
Vol. 218. no. 4569, pp. 286 - 289
DOI: 10.1126/science.7123233
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Articles

Science, Vol 218, Issue 4569, 286-289
Copyright © 1982 by American Association for the Advancement of Science

articles

Nonimmunological production of leukotrienes induced by platelet-activating factor

NF Voelkel, S Worthen, JT Reeves, PM Henson, and RC Murphy

Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Am. J. Respir. Crit. Care Med. 166, 657-662
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Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion.
V. Stangl, G. Baumann, K. Stangl, and S. B Felix (2002)
Cardiovasc Res 53, 12-30
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Role of Platelet-Activating Factor in Cardiovascular Pathophysiology.
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Physiol Rev 80, 1669-1699
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Bronchoalveolar Lavage Alterations in Pulmonary Embolism.
G. NAKOS, E. I. KITSIOULI, and M. E. LEKKA (1998)
Am. J. Respir. Crit. Care Med. 158, 1504-1510
   Abstract »    Full Text »    PDF »
Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats.
X.-W. Qu, R. A Rozenfeld, W. Huang, S. E Crawford, F Gonzalez-Crussi, and W. Hsueh (1998)
J. Physiol. 512, 227-234
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The Role of Platelet-Activating Factor in Regional Myocardial Ischemia-Reperfusion Injury.
A. K. Qayumi, J. C. English, D. V. Godin, D. M. Ansley, E. B. Loucks, J. U. Lee, and C.-W. Kim (1998)
Ann. Thorac. Surg. 65, 1690-1697
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Copper-Catalyzed Oxidation Mediates PAF Formation in Human LDL Subspecies : Protective Role of PAF:Acetylhydrolase in Dense LDL.
D. C. Tsoukatos, M. Arborati, T. Liapikos, K. L. Clay, R. C. Murphy, M. J. Chapman, and E. Ninio (1997)
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The Effects of 5-Lipoxygenase Inhibition by Zileuton on Platelet-activating-factor-induced Pulmonary Abnormalities in Mild Asthma.
F. P. GÓMEZ, R. IGLESIA, J. ROCA, J. A. BARBERÁ, K. FAN CHUNG, and R. RODRIGUEZ-ROISIN (1997)
Am. J. Respir. Crit. Care Med. 157, 1559-1564
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