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Science 15 October 1982:
Vol. 218. no. 4569, pp. 247 - 254
DOI: 10.1126/science.218.4569.247
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Articles

Mass Spectrometry of Large, Fragile, and Involatile Molecules

Kenneth L. Busch 1 and R. Graham Cooks 2

1 Assistant research scientist at Purdue University, West Lafayette, Indiana 47907
2 Professor of chemistry at Purdue University, West Lafayette, Indiana 47907

Desorption ionization makes it possible to obtain mass spectra of molecules whose vaporization by heating may lead to thermal degradation. Several methods are in use, but in general desorption is achieved by particle or photon bombardment of the sample and the mass spectra obtained by different methods are fundamentally similar. Desorption ionization techniques have been used to obtain mass spectra of biomolecules, including peptides, antibiotics, and oligosaccharides, for which normal mass spectral methods have been of limited power. Several examples are given of recent applications of these new techniques, and prospects for their further evolution are discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Focal Points in Mass Spectrometry.
W. N. Delgass, W. N. DELGASS, and R. G. COOKS (1987)
Science 235, 545-553
   Abstract »    PDF »
Fourier transform mass spectrometry.
M. Gross and D. Rempel (1984)
Science 226, 261-268
   Abstract »    PDF »
Mass spectrometry: analytical capabilities and potentials.
R. Cooks, K. Busch, and G. Glish (1983)
Science 222, 273-291
   Abstract »    PDF »
Fast Atom Bombardment Mass Spectrometry.
K. L. Rinehart Jr. (1982)
Science 218, 254-260
   Abstract »    PDF »


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