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Science 8 October 1982:
Vol. 218. no. 4568, pp. 160 - 162
DOI: 10.1126/science.6750790
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Articles

Science, Vol 218, Issue 4568, 160-162
Copyright © 1982 by American Association for the Advancement of Science

articles

Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

MB Nekola, A Horvath, LJ Ge, DH Coy, and AV Schally

A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Growth Differentiation Factor-9 Stimulates Proliferation but Suppresses the Follicle-Stimulating Hormone-Induced Differentiation of Cultured Granulosa Cells from Small Antral and Preovulatory Rat Follicles.
U.A. Vitt, M. Hayashi, C. Klein, and A.J.W. Hsueh (2000)
Biol Reprod 62, 370-377
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Science. ISSN 0036-8075 (print), 1095-9203 (online)