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Science 8 October 1982:
Vol. 218. no. 4568, pp. 156 - 158
DOI: 10.1126/science.7123226
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Articles

Science, Vol 218, Issue 4568, 156-158
Copyright © 1982 by American Association for the Advancement of Science

articles

Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo

L Morphis, A Constantopoulos, N Matsaniotis, and A Papaphilis

Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis.
C. M. P. Rodrigues, S. Sola, R. E. Castro, P. A. Laires, D. Brites, and J. J. G. Moura (2002)
J. Lipid Res. 43, 885-894
   Abstract »    Full Text »    PDF »
Bilirubin in the Brain: Distribution and Effects on Neurophysiological and Neurochemical Processes.
T. W. R. Hansen (1994)
Clinical Pediatrics 33, 452-459
   PDF »


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