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Science 8 October 1982:
Vol. 218. no. 4568, pp. 121 - 127
DOI: 10.1126/science.218.4568.121
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Articles

Sedimentation Field Flow Fractionation: Applications

J. J. Kirkland 1 and W. W. Yau 1

1 Staff scientists at the E. I. du Pont de Nemours & Company, Central Research and Development Department Experimental Station, Wilmington, Delaware 19898

Sedimentation field flow fractionation is a powerful, new, high-resolution separation method for a wide variety of colloids, micelles, particulates, and soluble macromolecules of biological interest. Advances in instrumentation allow sedimentation field flow fractionation operation with rotor speeds up to 32,000 revolutions per minute (sim85,000 gravities), which permits separation of materials as small as 5 x 105 molecular weight, depending on sample density. Compared to conventional centrifugation techniques, the gentle, mass-separating sedimentation field flow fractionation method is capable of higher resolution in shorter times.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sedimentation field flow fractionation of DNA's.
L. Schallinger, W. Yau, and J. Kirkland (1984)
Science 225, 434-437
   Abstract »    PDF »
A survey of separative techniques.
T. Maugh 2nd (1983)
Science 222, 259-266
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)