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Science 1 October 1982:
Vol. 218. no. 4567, pp. 64 - 66
DOI: 10.1126/science.6981843
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Articles

Science, Vol 218, Issue 4567, 64-66
Copyright © 1982 by American Association for the Advancement of Science

articles

Patterns of human local cerebral glucose metabolism during epileptic seizures

J Engel Jr, DE Kuhl, and ME Phelps

Ictal patterns of local cerebral metabolic rate have been studied in epileptic patients by positron computed tomography with 18F-labeled 2-fluoro-2-deoxy-D-glucose. Partial seizures were associated with activation of anatomic structures unique to each patient studied. Ictal increases and decreases in local cerebral metabolism were observed. Scans performed during generalized convulsions induced by electroshock demonstrated a diffuse ictal increase and postictal decrease in cerebral metabolism. Petit mal absences were associated with a diffuse increase in cerebral metabolic rate. The ictal fluorodeoxyglucose patterns obtained from patients do not resemble autoradiographic patterns obtained from common experimental animal models of epilepsy.


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