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Science 1 October 1982:
Vol. 218. no. 4567, pp. 58 - 61
DOI: 10.1126/science.7123218
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Articles

Science, Vol 218, Issue 4567, 58-61
Copyright © 1982 by American Association for the Advancement of Science

articles

Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine

RD Green, HK Proudfit, and SM Yeung

Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use.
B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau (1999)
Pharmacol. Rev. 51, 83-133
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