Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 October 1982:
Vol. 218. no. 4567, pp. 56 - 58
DOI: 10.1126/science.6181562
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4567, 56-58
Copyright © 1982 by American Association for the Advancement of Science

articles

Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin

G Gold, ML Gishizky, and GM Grodsky

Studies of isolated islets labeled with radioactive leucine show that glucose at a critical time "marks" islets in such a way as to cause preferential release of newly synthesized insulin. The preferential release of insulin from marked islets is relatively independent of subsequent secretagogues or rates of insulin secretion. Previous kinetic studies have indicated that the critical time at which marking occurs is after proinsulin biosynthesis but before the secretory event. Thus, secretory cells may regulate the diversion of newly synthesized material for immediate release as it is approaching or transiting the Golgi apparatus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Novel aspects of the molecular mechanisms controlling insulin secretion.
L. Eliasson, F. Abdulkader, M. Braun, J. Galvanovskis, M. B. Hoppa, and P. Rorsman (2008)
J. Physiol. 586, 3313-3324
   Abstract »    Full Text »    PDF »
Proteasome Inhibition Alters Glucose-stimulated (Pro)insulin Secretion and Turnover in Pancreatic {beta}-Cells.
K. Kitiphongspattana, C. E. Mathews, E. H. Leiter, and H. R. Gaskins (2005)
J. Biol. Chem. 280, 15727-15734
   Abstract »    Full Text »    PDF »
Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the {beta}-Cells of Rat Pancreatic Islets.
S. G. Straub, G. Shanmugam, and G. W.G. Sharp (2004)
Diabetes 53, 3179-3183
   Abstract »    Full Text »    PDF »
Desensitization of Insulin Secretion by Depolarizing Insulin Secretagogues.
I. Rustenbeck, A. Wienbergen, C. Bleck, and A. Jorns (2004)
Diabetes 53, S140-S150
   Abstract »    Full Text »    PDF »
Retention and stimulus-dependent recycling of dense core vesicle content in neuroendocrine cells.
R. A. Bauer, R. L. Overlease, J. L. Lieber, and J. K. Angleson (2004)
J. Cell Sci. 117, 2193-2202
   Abstract »    Full Text »    PDF »
Secretory Granule Exocytosis.
R. D. Burgoyne and A. Morgan (2003)
Physiol Rev 83, 581-632
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)