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Science 24 September 1982:
Vol. 217. no. 4566, pp. 1273 - 1276
DOI: 10.1126/science.7112131
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Articles

Science, Vol 217, Issue 4566, 1273-1276
Copyright © 1982 by American Association for the Advancement of Science

articles

Characterization of estrogen-concentrating hypothalamic neurons by their axonal projections

JI Morrell and DW Pfaff

A method combining steroid autoradiography and fluorescent dye retrograde neuroanatomical tracing has been devised. This method makes it possible to demonstrate that some estrogen-concentrating cells in the ventrolateral subdivision of the ventromedial nucleus of the rat hypothalamus are neurons that send axons to the dorsal midbrain. Other cells only concentrate estrogen or only project to the midbrain. Estrogen-concentrating neurons in the ventromedial hypothalamus that project to the dorsal midbrain are likely to transmit hormone-influenced signals that regulate circuits for reproductive or other behaviors or autonomic functions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hormonal-Neural Integration in the Female Rat Ventromedial Hypothalamus: Triple Labeling for Estrogen Receptor-{alpha}, Retrograde Tract Tracing from the Periaqueductal Gray, and Mating-Induced Fos Expression.
L. H. Calizo and L. M. Flanagan-Cato (2003)
Endocrinology 144, 5430-5440
   Abstract »    Full Text »    PDF »
Central Neuronal Circuit Innervating the Lordosis-Producing Muscles Defined by Transneuronal Transport of Pseudorabies Virus.
D. Daniels, R. R. Miselis, and L. M. Flanagan-Cato (1999)
J. Neurosci. 19, 2823-2833
   Abstract »    Full Text »    PDF »
Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus.
V. Luine, K. Renner, M Frankfurt, and E. Azmitia (1984)
Science 226, 1436-1439
   Abstract »    PDF »
Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis.
R. Harlan, B. Shivers, and D. Pfaff (1983)
Science 219, 1451-1453
   Abstract »    PDF »


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