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Science 24 September 1982:
Vol. 217. no. 4566, pp. 1265 - 1267
DOI: 10.1126/science.7112130
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Articles

Science, Vol 217, Issue 4566, 1265-1267
Copyright © 1982 by American Association for the Advancement of Science

articles

Transmethylation of phosphatidylethanolamine: an initial event in embryonic chicken lens fiber cell differentiation

PS Zelenka, DC Beebe, and DE Feagans

Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiber formation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)