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Science 24 September 1982: Vol. 217. no. 4566, pp. 1247 - 1249 DOI: 10.1126/science.6287580
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Articles
Science, Vol 217, Issue 4566, 1247-1249
Copyright © 1982 by American Association for the Advancement of Science
Numbers of receptor sites from Scatchard graphs: facts and fantasies
IM Klotz
Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.
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