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Science 17 September 1982:
Vol. 217. no. 4565, pp. 1161 - 1163
DOI: 10.1126/science.6287579
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Articles

Science, Vol 217, Issue 4565, 1161-1163
Copyright © 1982 by American Association for the Advancement of Science

articles

Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam

SE Lukas and RR Griffiths

Baboons implanted with intragastric catheters were given diazepam (10 milligrams per kilogram of body weight) twice daily for 45 consecutive days. On days 7 and 35, they were given intramuscular injections of the benzodiazepine receptor antagonist Ro 15-1788. Mild and intermediate withdrawal signs, including retching and vomiting, were observed after 7 days of diazepam, and more frequent and intense withdrawal signs, including tremor and convulsion, occurred after 35 days of diazepam. With the termination of the diazepam injections after 45 days, a mild to intermediate withdrawal syndrome was observed over the next 15-day period.


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