Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 September 1982:
Vol. 217. no. 4565, pp. 1161 - 1163
DOI: 10.1126/science.6287579
Prev | Table of Contents | Next

Articles

Science, Vol 217, Issue 4565, 1161-1163
Copyright © 1982 by American Association for the Advancement of Science

articles

Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam

SE Lukas and RR Griffiths

Baboons implanted with intragastric catheters were given diazepam (10 milligrams per kilogram of body weight) twice daily for 45 consecutive days. On days 7 and 35, they were given intramuscular injections of the benzodiazepine receptor antagonist Ro 15-1788. Mild and intermediate withdrawal signs, including retching and vomiting, were observed after 7 days of diazepam, and more frequent and intense withdrawal signs, including tremor and convulsion, occurred after 35 days of diazepam. With the termination of the diazepam injections after 45 days, a mild to intermediate withdrawal syndrome was observed over the next 15-day period.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Efficacy and the Discriminative Stimulus Effects of Negative GABAA Modulators, or Inverse Agonists, in Diazepam-Treated Rhesus Monkeys.
L. R. McMahon, L. R. Gerak, and C. P. France (2006)
J. Pharmacol. Exp. Ther. 318, 907-913
   Abstract »    Full Text »    PDF »
Part 10.2: Toxicology in ECC.
(2005)
Circulation 112, IV-126-IV-132
   Full Text »    PDF »
Discriminative Stimulus Effects of Positive GABAA Modulators and Other Anxiolytics, Sedatives, and Anticonvulsants in Untreated and Diazepam-Treated Monkeys.
L. R. McMahon and C. P. France (2003)
J. Pharmacol. Exp. Ther. 304, 109-120
   Abstract »    Full Text »    PDF »
Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of gamma -Aminobutyric AcidA Modulators on Schedule-Controlled Responding in Rhesus Monkeys.
L. R. McMahon and C. P. France (2002)
J. Pharmacol. Exp. Ther. 300, 1017-1025
   Abstract »    Full Text »    PDF »
Zolpidem Physical Dependence Assessed Across Increasing Doses Under a Once-Daily Dosing Regimen in Baboons.
E. M. Weerts, N. A. Ator, D. M. Grech, and R. R. Griffiths (1998)
J. Pharmacol. Exp. Ther. 285, 41-53
   Abstract »    Full Text »
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users.
M.A. Bernik, C. Gorenstein, and A.H.G. Vieira Filho (1998)
J Psychopharmacol 12, 146-150
   Abstract »    PDF »
Flumazenil-precipitated withdrawal symptoms in chronic users of therapeutic doses of diazepam.
M. A. Bernik, C. Gorenstein, and V. Gentil (1991)
J Psychopharmacol 5, 215-219
   Abstract »    PDF »
Kindling and withdrawal changes at the benzodiazepine receptor.
H. J. Little, D. J. Nutt, and S. C. Taylor (1987)
J Psychopharmacol 1, 35-46
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)