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Science 17 September 1982:
Vol. 217. no. 4565, pp. 1157 - 1159
DOI: 10.1126/science.6287578
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Articles

Science, Vol 217, Issue 4565, 1157-1159
Copyright © 1982 by American Association for the Advancement of Science

articles

Stereoselective antagonism of phencyclidine's discriminative properties by adenosine receptor agonists

RG Browne and WM Welch

Rats trained to discriminate between phencyclidine and saline vehicle were used to test various agents for their ability to mimic or block the phencyclidine cue. ketamine, dexoxadrol, tiletamine, and phencyclidine analogs were found to mimic phencyclidine's behavioral effects. Treatment with the adenosime receptor agonists N6-cyclohexyladenosine and L-phenylisopropyladenosine blocked the discriminative properties of phencyclidine. These results suggest that adenosine receptor agonists might be useful in treating phencyclidine-induced psychosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of MK-801-Induced Behavior as a Putative Rat Model of Psychosis.
P. Andiné, N. Widermark, R. Axelsson, G. Nyberg, U. Olofsson, E. Mårtensson, and M. Sandberg (1999)
J. Pharmacol. Exp. Ther. 290, 1393-1408
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