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Science 17 September 1982:
Vol. 217. no. 4565, pp. 1153 - 1155
DOI: 10.1126/science.7112122
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Articles

Science, Vol 217, Issue 4565, 1153-1155
Copyright © 1982 by American Association for the Advancement of Science

articles

Type II collagen autoimmunity in otosclerosis and Meniere's Disease

TJ Yoo, JM Stuart, AH Kang, AS Townes, K Tomoda, and S Dixit

Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.


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Type II collagen-induced autoimmune endolymphatic hydrops in guinea pig.
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Science 222, 65-67
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R. Chole and K. Henry (1983)
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