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Science 10 September 1982:
Vol. 217. no. 4564, pp. 1053 - 1055
DOI: 10.1126/science.7112111
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Articles

Science, Vol 217, Issue 4564, 1053-1055
Copyright © 1982 by American Association for the Advancement of Science

articles

Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam

DP Perl, DC Gajdusek, RM Garruto, RT Yanagihara, and CJ Gibbs

Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicate prominent accumulation of aluminum within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.


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