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Science 10 September 1982:
Vol. 217. no. 4564, pp. 1050 - 1053
DOI: 10.1126/science.7051286
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Articles

Science, Vol 217, Issue 4564, 1050-1053
Copyright © 1982 by American Association for the Advancement of Science

articles

Myocardial injury: quantitation by cell sorting initiated with antimyosin fluorescent spheres

BA Khaw, J Scott, JT Fallon, SL Cahill, E Haber, and C Homcy

Spheres coated with antibodies specific for myosin were used to detect myocardial cell membrane disruption by scanning electron microscopy. Injury in a population of cultured myocytes as then followed and measured by fluorescence-activated cell sorting. This approach provides a unique method for quantitating the evolution of myocardial injury and potentially for assessing the efficacy of interventions aimed at myocardial protection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of Noninvasive Antimyosin Imaging in Infants and Children with Clinically Suspected Myocarditis.
M. E. R. Martin, J. L. Moya-Mur, M. Casanova, A. Crespo-Diez, E. Asin-Cardiel, J. M. Castro-Beiras, L. Diez-Jimenez, M. Ballester, I. Carrio, and J. Narula (2004)
J. Nucl. Med. 45, 429-437
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Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms.
L. Sarda, P. Colin, F. Boccara, D. Daou, R. Lebtahi, M. Faraggi, C. Nguyen, A. Cohen, M. S. Slama, P. G. Steg, et al. (2001)
J. Am. Coll. Cardiol. 37, 786-792
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Myocardial cell damage in human hypertension.
G. Pons-Llado, M. Ballester, X. Borras, F. Carreras, I. Carrio, J. Lopez-Contreras, A. Roca-Cusachs, J. Marrugat, and J. Narula (2000)
J. Am. Coll. Cardiol. 36, 2198-2203
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111Indium antimyosin antibody imaging of primary myocardial invovement in systemic diseases.
L Sarda, P Assayag, E Palazzo, D Vilain, L Guillevin, M Faraggi, O Meyer, and D Le Guludec (1999)
Ann Rheum Dis 58, 90-95
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Evaluation of Myocardial Cell Damage by In-111-Monoclonal Antimyosin Antibodies in Patients Under Chronic Tricyclic Antidepressant Drug Treatment.
V. Marti, M. Ballester, C. Udina, I. Carrio, E. Alvarez, D. Obrador, and G. Pons-Llado (1995)
Circulation 91, 1619-1623
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Indium 111--Monoclonal Antimyosin Antibody and Magnetic Resonance Imaging in the Diagnosis of Acute Lyme Myopericarditis.
J. Bergler-Klein, H. Sochor, G. Stanek, S. Globits, R. Ullrich, and D. Glogar (1993)
Arch Intern Med 153, 2696-2700
   Abstract »    PDF »
Recognition of Acute Myocarditis Masquerading as Acute Myocardial Infarction.
J. Narula, B. A. Khaw, G. W. Dec, I. F. Palacios, J. F. Southern, J. T. Fallon, H. W. Strauss, E. Haber, and T. Yasuda (1993)
N. Engl. J. Med. 328, 100-104
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Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes.
K. Bloch, J. Scott, J. Zisfein, J. Fallon, M. Margolies, C. Seidman, G. Matsueda, C. Homcy, R. Graham, and J. Seidman (1985)
Science 230, 1168-1171
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