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Science 10 September 1982:
Vol. 217. no. 4564, pp. 1044 - 1046
DOI: 10.1126/science.6810463
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Articles

Science, Vol 217, Issue 4564, 1044-1046
Copyright © 1982 by American Association for the Advancement of Science

articles

Polyamine depletion influences drug-induced chromosomal damage

PJ Tofilon, SM Oredsson, DF Deen, and LJ Marton

Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.


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