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Science 10 September 1982:
Vol. 217. no. 4564, pp. 1040 - 1042
DOI: 10.1126/science.6810462
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Articles

Science, Vol 217, Issue 4564, 1040-1042
Copyright © 1982 by American Association for the Advancement of Science

articles

Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs

WE Klunk, A McKeon, DF Covey, and JA Ferrendelli

Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Neurosci. 18, 5103-5111
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Inhibition of Voltage-Dependent Sodium Channels by the Anticonvulsant gamma -Aminobutyric Acid Type A Receptor Modulator, 3-Benzyl-3-Ethyl-2-Piperidinone.
M. W. Hill, P. A. Reddy, D. F. Covey, and S. M. Rothman (1998)
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Lactone Modulation of the gamma -Aminobutyric Acid A Receptor: Evidence for a Positive Modulatory Site.
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