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Science 3 September 1982:
Vol. 217. no. 4563, pp. 937 - 939
DOI: 10.1126/science.6287573
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Articles

Science, Vol 217, Issue 4563, 937-939
Copyright © 1982 by American Association for the Advancement of Science

articles

Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus

N Tsuchida,, E Ohtsubo, and T Ryder

The transforming protein ofKirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.


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