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Science 3 September 1982:
Vol. 217. no. 4563, pp. 934 - 936
DOI: 10.1126/science.6287572
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Articles

Science, Vol 217, Issue 4563, 934-936
Copyright © 1982 by American Association for the Advancement of Science

articles

Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus

R Dhar, RW Ellis, TY Shih, S Oroszlan, B Shapiro, J Maizel, D Lowy, and E Scolnick

Harvey murine sarcoma virus is a retrovirus which transforms cells by means of a single virally encoded protein called p21 has. We have determined the nucleotide sequence of 1.0 kilobase in the 5' half of the viral genome which encompasses the has coding sequences and its associated regulatory signals. The nucleotide sequence has identified the amino acid sequence of two additional overlapping polypeptides which share their reading frames and the carboxyl termini with p21 but which contain additional NH2-terminal amino acids.


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