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Science 27 August 1982:
Vol. 217. no. 4562, pp. 860 - 861
DOI: 10.1126/science.7100931
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Articles

Science, Vol 217, Issue 4562, 860-861
Copyright © 1982 by American Association for the Advancement of Science

articles

Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site

M Nieto-Sampedro, ER Lewis, CW Cotman, M Manthorpe, SD Skaper, G Barbin, FM Longo, and S Varon

A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.


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