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Science 27 August 1982:
Vol. 217. no. 4562, pp. 801 - 806
DOI: 10.1126/science.6285471
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Articles

Science, Vol 217, Issue 4562, 801-806
Copyright © 1982 by American Association for the Advancement of Science

articles

Cellular transforming genes

GM Cooper

Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.


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