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Science 20 August 1982:
Vol. 217. no. 4561, pp. 745 - 747
DOI: 10.1126/science.6285470
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Articles

Science, Vol 217, Issue 4561, 745-747
Copyright © 1982 by American Association for the Advancement of Science

articles

Prolactin and growth hormone release by morphine in the rat: different receptor mechanisms

K Spiegel, IA Kourides, and GW Pasternak

Concentrations of prolactin and growth hormone in the serum of rats were significantly increased by morphine. Dose response studies demonstrated that maximum prolactin release required lower doses of morphine than those needed for the maximum growth hormone response. Selective blockade of mu 1 (high affinity) opiate receptor with the irreversible antagonist naloxazone reduced morphine-induced peak concentrations of prolactin by 80 percent while increasing peak growth hormone levels by 250 percent. These results suggest different receptor mechanisms for the opiate modulation of the two hormones. The mu 1 (high affinity) receptor sites appear to mediate the morphine-induced release of prolactin but not growth hormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pituitary Gland: Neuropeptides, Neurotransmitters and Growth Factors.
J. I. Koenig (1989)
Toxicol Pathol 17, 256-265
   Abstract »    PDF »
Separation of morphine analgesia from physical dependence.
G. Ling, J. MacLeod, S Lee, S. Lockhart, and G. Pasternak (1984)
Science 226, 462-464
   Abstract »    PDF »


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