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Science 20 August 1982:
Vol. 217. no. 4561, pp. 733 - 735
DOI: 10.1126/science.7100920
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Articles

Science, Vol 217, Issue 4561, 733-735
Copyright © 1982 by American Association for the Advancement of Science

articles

Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig

A Kornhauser, WG Wamer, and AL Giles Jr

Serum and epidermal concentrations of 8-methoxypsoralen and 5-methoxypsoralen 2 hours after oral administration to guinea pigs were determined by high-performance liquid chromatography. A linear relation was found between the serum and epidermal concentrations of 8-methoxypsoralen. In addition, a relation was found between serum concentrations of 5-methoxypsoralen and 8-methoxypsoralen and the appearance of phototoxicity. The lower phototoxicity of orally administered 5-methoxypsoralen as compared to 8-methoxypsoralen in the guinea pig appears to be due to its reduced concentrations in the epidermis, the primary site of the phototoxic events.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Variations in Plasma Levels With 12 Different Forms of Methoxsalen.
R. Roelandts, M. Van Boven, H. De Greef, R. Kinget, P. Adriaens, and P. Daenens (1985)
Arch Dermatol 121, 173
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