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Science 13 August 1982:
Vol. 217. no. 4560, pp. 645 - 647
DOI: 10.1126/science.6806905
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Articles

Science, Vol 217, Issue 4560, 645-647
Copyright © 1982 by American Association for the Advancement of Science

articles

Metabolism of 2,4',5-trichlorobiphenyl by the mercapturic acid pathway

JE Bakke, AL Bergman, and GL Larsen

Carbon-14-labeled 2,4',5-trichlorobiphenyl was found to be metabolized by the mercapturic acid pathway to metabolites that are excreted in bile. About 57 percent of the carbon-14 was excreted in the bile; 30 to 35 percent was present as mercapturic acid pathway metabolites. Mercapturic acid was also isolated from the urine (0.3 percent of the dose).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
COMPARATIVE METABOLISM OF POLYCHLORINATED BIPHENYLS AND TISSUE DISTRIBUTION OF PERSISTENT METABOLITES IN RATS, HAMSTERS, AND GUINEA PIGS.
K. Haraguchi, N. Koga, and Y. Kato (2005)
Drug Metab. Dispos. 33, 373-380
   Abstract »    Full Text »    PDF »
Cytochrome P450-Catalyzed Binding of 3-Methylsulfonyl-DDE and o,p'-DDD in Human Adrenal Zona Fasciculata/Reticularis.
O. Lindhe, B. Skogseid, and I. Brandt (2002)
J. Clin. Endocrinol. Metab. 87, 1319-1326
   Abstract »    Full Text »    PDF »
Comparative Study on Formation of Hydroxy and Sulfur-Containing Metabolites from Different Chlorinated Biphenyls with 2,5-Substitution in Rats.
K. Haraguchi, Y. Kato, R. Kimura, and Y. Masuda (1997)
Drug Metab. Dispos. 25, 845-852
   Abstract »    Full Text »
Limited Role of the Intestinal Microflora in the Nephrotoxicity of Hexachloro-1,3-Butadiene in Rats.
A. Wallin, K. Ormstad, and T. Midtvedt (1993)
Toxicol Pathol 21, 443-448
   Abstract »    PDF »


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