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Science 6 August 1982:
Vol. 217. no. 4559, pp. 553 - 555
DOI: 10.1126/science.7089581
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Articles

Science, Vol 217, Issue 4559, 553-555
Copyright © 1982 by American Association for the Advancement of Science

articles

Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats

BS Bregman and ME Goldberger

Spinal cord damage in neonatal cats has different effects on different spinal pathways. Corticospinal projections exhibit anatomical plasticity, forming an aberrant pathway that bypasses the lesion. In contrast, brainstem-spinal pathways undergo massive retrograde degeneration. Neither of these responses occurs in adult cats. Sparing of motor function is found in cats operated on as neonates but not in cats operated on as adults, and appears to depend on the plasticity of the corticospinal tract.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Physical Therapy 88, 580-590
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Changes in Motoneuron Properties and Synaptic Inputs Related to Step Training after Spinal Cord Transection in Rats.
J. C. Petruska, R. M. Ichiyama, D. L. Jindrich, E. D. Crown, K. E. Tansey, R. R. Roy, V. R. Edgerton, and L. M. Mendell (2007)
J. Neurosci. 27, 4460-4471
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Recapitulate development to promote axonal regeneration: good or bad approach?.
M. T Filbin (2006)
Phil Trans R Soc B 361, 1565-1574
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Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotrophins.
J. V. Coumans, T. T.-S. Lin, H. N. Dai, L. MacArthur, M. McAtee, C. Nash, and B. S. Bregman (2001)
J. Neurosci. 21, 9334-9344
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Neuronal Cyclic AMP Controls the Developmental Loss in Ability of Axons to Regenerate.
D. Cai, J. Qiu, Z. Cao, M. McAtee, B. S. Bregman, and M. T. Filbin (2001)
J. Neurosci. 21, 4731-4739
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Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury.
N. Weidner, A. Ner, N. Salimi, and M. H. Tuszynski (2001)
PNAS 98, 3513-3518
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EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.
M. Dottori, L. Hartley, M. Galea, G. Paxinos, M. Polizzotto, T. Kilpatrick, P. F. Bartlett, M. Murphy, F. Kontgen, and A. W. Boyd (1998)
PNAS 95, 13248-13253
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