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Science 6 August 1982:
Vol. 217. no. 4559, pp. 540 - 542
DOI: 10.1126/science.7046053
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Articles

Science, Vol 217, Issue 4559, 540-542
Copyright © 1982 by American Association for the Advancement of Science

articles

Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin

KV Honn, P Cavanaugh, C Evens, JD Taylor, and BF Sloane

The ability of tumor cells to metastasize may be related to their ability to promote aggregation of host platelets. The use of inhibitors of cysteine proteinases resulted in parallel inhibition of B16 amelanotic melanoma-induced platelet aggregation and of a cathepsin B activity. The antimetastatic agent prostacyclin inhibited platelet aggregation induced by the tumor cells and by papain, a cathepsin B-mimicking agent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Metastases by Anticoagulants.
M. Hejna, M. Raderer, and C. C. Zielinski (1999)
J Natl Cancer Inst 91, 22-36
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