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Science 6 August 1982:
Vol. 217. no. 4559, pp. 535 - 537
DOI: 10.1126/science.7089579
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Articles

Science, Vol 217, Issue 4559, 535-537
Copyright © 1982 by American Association for the Advancement of Science

articles

Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex Reversal

EM Eicher LL Washburn JB Whitney, 3rd and KE Morrow

When the Y chromosome from Mus poschiavinus (YPOS) is transferred onto the C57BL/6J genome, XY individuals develop as females with two ovaries, or as hermaphrodites. No XY individual develops normal testes. Although C57BL/6J-YPOS XY females are rarely fertile, most hermaphrodites with normal male genitalia sire offspring. Thus, the Mus poschiavinus Y chromosome carries a form of the Y-linked testis-determining locus different from that present in the C57BL/6J inbred strain. This gene interacts abnormally with autosomal or X-linked testis-determining loci of the CS7BL/6J genome to prevent normal testicular differentiation. Divergence of the Y-linked testis-determining gene may be involved in mammalian speciation.


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