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Science 30 July 1982:
Vol. 217. no. 4558, pp. 463 - 464
DOI: 10.1126/science.6178163
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Articles

Science, Vol 217, Issue 4558, 463-464
Copyright © 1982 by American Association for the Advancement of Science

articles

Deficiency of functional messenger RNA for a developmentally regulated beta-crystallin polypeptide in a hereditary cataract

D Carper

The messenger RNA for a beta-crystallin polypeptide with a molecular size of 27 kilodaltons, first detected 5 to 10 days after birth in the normal mouse lens and the Nakano mouse cataract, was not detected in the Philly mouse cataract with translation in vitro. The heterozygous Philly lens had intermediate levels of the 27-kilodalton beta-crystallin polypeptide and exhibited delayed onset of the cataract. The deficiency of functional 27-kilodalton beta-crystallin messenger RNA is the earliest lesion reported yet for the Philly lens and points to a transcriptional or posttranscriptional developmental defect in this hereditary cataract.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic Heterogeneity of the Coppock-like Cataract: A Mutation in CRYBB2 on Chromosome 22q11.2.
D. Gill, R. Klose, F. L. Munier, M. McFadden, M. Priston, G. Billingsley, N. Ducrey, D. F. Schorderet, and E. Héon (2000)
Invest. Ophthalmol. Vis. Sci. 41, 159-165
   Abstract »    Full Text »
Selective loss of a family of gene transcripts in a hereditary murine cataract.
A. Garber, C Winkler, T Shinohara, C. King, G Inana, J Piatigorsky, and R. Gold (1985)
Science 227, 74-77
   Abstract »    PDF »


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