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Science 30 July 1982:
Vol. 217. no. 4558, pp. 458 - 460
DOI: 10.1126/science.6283637
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Articles

Science, Vol 217, Issue 4558, 458-460
Copyright © 1982 by American Association for the Advancement of Science

articles

Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane

FS Cohen, MH Akabas, and A Finkelstein

Fusion of phospholipid vesicles with planar bilayer membranes occurs if the vesicles that contact the planar membrane swell osmotically after the replacement in their medium of an impermeant solute by a permeant one. This finding directly demonstrates that osmotic swelling is a driving force for vesicle-planar membrane fusion. The method used to induce vesicle swelling and fusion may have relevance for biological systems.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Time-resolved Imaging of HIV-1 Env-mediated Lipid and Content Mixing between a Single Virion and Cell Membrane.
R. M. Markosyan, F. S. Cohen, and G. B. Melikyan (2005)
Mol. Biol. Cell 16, 5502-5513
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