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Science 30 July 1982:
Vol. 217. no. 4558, pp. 452 - 454
DOI: 10.1126/science.7089575
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Articles

Science, Vol 217, Issue 4558, 452-454
Copyright © 1982 by American Association for the Advancement of Science

articles

Cysteamine: a potent and specific depletor of pituitary prolactin

WJ Millard, SM Sagar, DM Landis, and JB Martin

Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)