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Science 30 July 1982:
Vol. 217. no. 4558, pp. 451 - 452
DOI: 10.1126/science.6979782
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Articles

Science, Vol 217, Issue 4558, 451-452
Copyright © 1982 by American Association for the Advancement of Science

articles

24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks?

S Ameenuddin, M Sunde, HF DeLuca, N Ikekawa, and Y Kobayashi

As shown previously, laying hens given 1,25-dihydroxyvitamin D3 as their sole source of vitamin D produce fertile eggs having normal shells, but only 35 to 55 percent of the embryos are normal. Giving these hens additional 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 at 1.25 nanomoles per day resulted in 90 to 100 percent normal embryos, and hence, hatchability. Since 24,24-difluoro-25-hydroxyvitamin D3 cannot be 24-hydroxylated, 24-hydroxylation is not required for this function of 25-hydroxyvitamin D3.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
24R,25-Dihydroxyvitamin D3: An Essential Vitamin D3 Metabolite for Both Normal Bone Integrity and Healing of Tibial Fracture in Chicks.
E.-G. Seo, T. A. Einhorn, and A. W. Norman (1997)
Endocrinology 138, 3864-3872
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)