Science 30 July 1982: Vol. 217. no. 4558, pp. 408 - 414 DOI: 10.1126/science.7046051

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Articles

Cholinergic Stimulation Enhances Neural Activity Associated with Encoding but Reduces Neural Activity Associated with Retrieval in Humans.

J. Kukolja, C. M. Thiel, and G. R. Fink (2009)
J. Neurosci. 29, 8119-8128
 |  Abstract »  |  Full Text »  |  PDF »

Nicotine enhances automatic temporal processing as measured by the mismatch negativity waveform.

L. F. Martin, D. B. Davalos, and M. A. Kisley (2009)
Nicotine Tob Res 11, 698-706
 |  Abstract »  |  Full Text »  |  PDF »

The Activation of M1 Muscarinic Receptor Signaling Induces Neuronal Differentiation in Pyramidal Hippocampal Neurons.

K. L. VanDeMark, M. Guizzetti, G. Giordano, and L. G. Costa (2009)
J. Pharmacol. Exp. Ther. 329, 532-542
 |  Abstract »  |  Full Text »  |  PDF »

Procognitive and Neuroprotective Activity of a Novel {alpha}7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders.

R. Roncarati, C. Scali, T. A. Comery, S. M. Grauer, S. Aschmi, H. Bothmann, B. Jow, D. Kowal, M. Gianfriddo, C. Kelley, et al. (2009)
J. Pharmacol. Exp. Ther. 329, 459-468
 |  Abstract »  |  Full Text »  |  PDF »

The Fast and Slow Afterhyperpolarizations Are Differentially Modulated in Hippocampal Neurons by Aging and Learning.

E. A. Matthews, J. M. Linardakis, and J. F. Disterhoft (2009)
J. Neurosci. 29, 4750-4755
 |  Abstract »  |  Full Text »  |  PDF »

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection.

S. D. Buckingham, A. K. Jones, L. A. Brown, and D. B. Sattelle (2009)
Pharmacol. Rev. 61, 39-61
 |  Abstract »  |  Full Text »  |  PDF »

The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease.

J. W Wright and J. W Harding (2008)
Journal of Renin-Angiotensin-Aldosterone System 9, 226-237
 |  Abstract »  |  PDF »

Modulation of Neuritogenesis by Astrocyte Muscarinic Receptors.

M. Guizzetti, N. H. Moore, G. Giordano, and L. G. Costa (2008)
J. Biol. Chem. 283, 31884-31897
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.

V. Nimmrich, R. Szabo, C. Nyakas, I. Granic, K. G. Reymann, U. H. Schroder, G. Gross, H. Schoemaker, K. Wicke, A. Moller, et al. (2008)
J. Pharmacol. Exp. Ther. 327, 343-352
 |  Abstract »  |  Full Text »  |  PDF »

Brain cholinergic impairment in liver failure.

M.-S. Garcia-Ayllon, O. Cauli, M.-X. Silveyra, R. Rodrigo, A. Candela, A. Compan, R. Jover, M. Perez-Mateo, S. Martinez, V. Felipo, et al. (2008)
Brain 131, 2946-2956
 |  Abstract »  |  Full Text »  |  PDF »

Acetylcholinesterase Inhibitor in Combination With Cognitive Training in Older Adults.

J. A. Yesavage, L. Friedman, J. W. Ashford, H. C. Kraemer, M. S. Mumenthaler, A. Noda, and J. Hoblyn (2008)
J. Gerontol. B. Psychol. Sci. Soc. Sci. 63, P288-P294
 |  Abstract »  |  Full Text »  |  PDF »

Functional Convergence of Dopaminergic and Cholinergic Input Is Critical for Hippocampus-Dependent Working Memory.

L. A. B. Wisman, G. Sahin, M. Maingay, G. Leanza, and D. Kirik (2008)
J. Neurosci. 28, 7797-7807
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence.

T. T. Hshieh, T. G. Fong, E. R. Marcantonio, and S. K. Inouye (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 764-772
 |  Abstract »  |  Full Text »  |  PDF »

Comprehensive approach of donepezil and psychosocial interventions on cognitive function and quality of life for Alzheimer's disease: the Osaki-Tajiri Project.

M. Meguro, M. Kasai, K. Akanuma, H. Ishii, S. Yamaguchi, and K. Meguro (2008)
Age Ageing 37, 469-473
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Activation of the Medial Septum Reverses Age-Related Hippocampal Encoding Deficits: A Place Field Analysis.

S. Sava and E. J. Markus (2008)
J. Neurosci. 28, 1841-1853
 |  Abstract »  |  Full Text »  |  PDF »

Neurocognitive Costs and Benefits of Psychotropic Medications in Older Adults.

J. O. Brooks and J. C. Hoblyn (2007)
J Geriatr Psychiatry Neurol 20, 199-214
 |  Abstract »  |  PDF »

Nitric Oxide Activates Leak K+ Currents in the Presumed Cholinergic Neuron of Basal Forebrain.

Y. Kang, Y. Dempo, A. Ohashi, M. Saito, H. Toyoda, H. Sato, H. Koshino, Y. Maeda, and T. Hirai (2007)
J Neurophysiol 98, 3397-3410
 |  Abstract »  |  Full Text »  |  PDF »

Alteration of Neurotrophins in the Hippocampus and Cerebral Cortex of Young Rats Exposed to Chlorpyrifos and Methyl Parathion.

A. M. Betancourt, N. M. Filipov, and R. L. Carr (2007)
Toxicol. Sci. 100, 445-455
 |  Abstract »  |  Full Text »  |  PDF »

Acori graminei rhizoma Ameliorated Ibotenic Acid-Induced Amnesia in Rats.

J. H. Kim, D.-H. Hahm, H.-J. Lee, K. H. Pyun, and I. Shim (2007)
Evid. Based Complement. Altern. Med.
 |  Abstract »  |  Full Text »  |  PDF »

Should One Use Medications in Combination With Cognitive Training? If So, Which Ones?.

J. Yesavage, J. Hoblyn, L. Friedman, M. Mumenthaler, B. Schneider, and R. O'Hara (2007)
J. Gerontol. B. Psychol. Sci. Soc. Sci. 62, 11-18
 |  Abstract »  |  Full Text »  |  PDF »

Active {beta}-Amyloid Immunization Restores Spatial Learning in PDAPP Mice Displaying Very Low Levels of {beta}-Amyloid.

G. Chen, K. S. Chen, D. Kobayashi, R. Barbour, R. Motter, D. Games, S. J. Martin, and R. G. M. Morris (2007)
J. Neurosci. 27, 2654-2662
 |  Abstract »  |  Full Text »  |  PDF »

Noncholinergic Lesions of the Medial Septum Impair Sequential Learning of Different Spatial Locations.

T. A. Dwyer, R. J. Servatius, and K. C. H. Pang (2007)
J. Neurosci. 27, 299-303
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice.

M. Rosato-Siri, A. Cattaneo, and E. Cherubini (2006)
J. Physiol. 576, 361-377
 |  Abstract »  |  Full Text »  |  PDF »

Sleep to Remember.

J. Born, B. Rasch, and S. Gais (2006)
Neuroscientist 12, 410-424
 |  Abstract »  |  PDF »

Alzheimer's disease and anaesthesia: implications for the central cholinergic system.

V. Fodale, D. Quattrone, C. Trecroci, V. Caminiti, and L. B. Santamaria (2006)
Br. J. Anaesth. 97, 445-452
 |  Abstract »  |  Full Text »  |  PDF »

Use of Antidementia Agents in Vascular Dementia: Beyond Alzheimer Disease.

M. R. Farlow (2006)
Mayo Clin. Proc. 81, 1350-1358
 |  Abstract »  |  Full Text »  |  PDF »

Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing!.

N. Tabet (2006)
Age Ageing 35, 336-338
 |  Abstract »  |  Full Text »  |  PDF »

Inflammation and neurodegenerative diseases.

W S. T Griffin (2006)
Am. J. Clinical Nutrition 83, 470S-474S
 |  Abstract »  |  Full Text »  |  PDF »

Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant Insults In Vitro and In Vivo.

T. Chiba, M. Yamada, Y. Hashimoto, M. Sato, J. Sasabe, Y. Kita, K. Terashita, S. Aiso, I. Nishimoto, and M. Matsuoka (2005)
J. Neurosci. 25, 10252-10261
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Inhibition of Neocortical Pyramidal Neurons.

A. T. Gulledge and G. J. Stuart (2005)
J. Neurosci. 25, 10308-10320
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Modulation of Prefrontal Cortical Activity During a Working Memory Task in Young and Older Humans: A PET Study With Physostigmine.

U. Freo, E. Ricciardi, P. Pietrini, M. B. Schapiro, S. I. Rapoport, and M. L. Furey (2005)
Am J Psychiatry 162, 2061-2070
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning.

A. Fontan-Lozano, J. Troncoso, A. Munera, A. M. Carrion, and J. M. Delgado-Garcia (2005)
Learn. Mem. 12, 557-563
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor-Independent Neuronal Survival: A Role for NO Donors.

K. Akassoglou (2005)
Mol. Pharmacol. 68, 952-955
 |  Abstract »  |  Full Text »  |  PDF »

Increased Susceptibility to Adult Paraoxon Exposure in Mice Neonatally Exposed to Nicotine.

E. Ankarberg, A. Fredriksson, and P. Eriksson (2004)
Toxicol. Sci. 82, 555-561
 |  Abstract »  |  Full Text »  |  PDF »

M2 Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity.

T. Seeger, I. Fedorova, F. Zheng, T. Miyakawa, E. Koustova, J. Gomeza, A. S. Basile, C. Alzheimer, and J. Wess (2004)
J. Neurosci. 24, 10117-10127
 |  Abstract »  |  Full Text »  |  PDF »

Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA.

M. A. Bruno, P. B. S. Clarke, A. Seltzer, R. Quirion, K. Burgess, A. C. Cuello, and H. U. Saragovi (2004)
J. Neurosci. 24, 8009-8018
 |  Abstract »  |  Full Text »  |  PDF »

Allosteric Modulators: The New Generation of Receptor Antagonist.

T. Kenakin (2004)
Mol. Interv. 4, 222-229
 |  Abstract »  |  Full Text »  |  PDF »

Imaging of Muscarinic Acetylcholine Receptor Signaling in Hippocampal Neurons: Evidence for Phosphorylation-Dependent and -Independent Regulation by G-Protein-Coupled Receptor Kinases.

J. M. Willets, M. S. Nash, R. A. J. Challiss, and S. R. Nahorski (2004)
J. Neurosci. 24, 4157-4162
 |  Abstract »  |  Full Text »  |  PDF »

The Cholinergic Lesion of Alzheimer's Disease: Pivotal Factor or Side Show?.

M. Mesulam (2004)
Learn. Mem. 11, 43-49
 |  Abstract »  |  Full Text »  |  PDF »

Extensive Lesions of Cholinergic Basal Forebrain Neurons Do Not Impair Spatial Working Memory.

J. A. Vuckovich, M. E. Semel, and M. G. Baxter (2004)
Learn. Mem. 11, 87-94
 |  Abstract »  |  Full Text »  |  PDF »

Galantamine Facilitates Acquisition of Hippocampus-Dependent Trace Eyeblink Conditioning in Aged Rabbits.

A. P. Weible, M. M. Oh, G. Lee, and J. F. Disterhoft (2004)
Learn. Mem. 11, 108-115
 |  Abstract »  |  Full Text »  |  PDF »

Galantamine Facilitates Acquisition of a Trace-Conditioned Eyeblink Response in Healthy, Young Rabbits.

B. B. Simon, B. Knuckley, and D. A. Powell (2004)
Learn. Mem. 11, 116-122
 |  Abstract »  |  Full Text »  |  PDF »

Normal Genetic Variation, Cognition, and Aging.

P. M. Greenwood and R. Parasuraman (2003)
Behav Cogn Neurosci Rev 2, 278-306
 |  Abstract »  |  PDF »

Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors.

M. Wu, S. S. Newton, J. B. Atkins, C. Xu, R. S. Duman, and M. Alreja (2003)
J. Pharmacol. Exp. Ther. 307, 535-543
 |  Abstract »  |  Full Text »  |  PDF »

Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain Development.

H. Viberg, A. Fredriksson, E. Jakobsson, U. Orn, and P. Eriksson (2003)
Toxicol. Sci. 76, 112-120
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide-Mediated Cortical Activation: A Diffuse Wake-Up System.

J. Marino and J. Cudeiro (2003)
J. Neurosci. 23, 4299-4307
 |  Abstract »  |  Full Text »  |  PDF »

Galanin in Alzheimer Disease.

S. E. Counts, S. E. Perez, S. D. Ginsberg, S. de Lacalle, and E. J. Mufson (2003)
Mol. Interv. 3, 137-156
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the Ras-GRF1 Exchange Factor at Ser916/898 Reveals Activation of Ras Signaling in the Cerebral Cortex.

H. Yang, D. Cooley, J. E. Legakis, Q. Ge, R. Andrade, and R. R. Mattingly (2003)
J. Biol. Chem. 278, 13278-13285
 |  Abstract »  |  Full Text »  |  PDF »

A Review of Cholinergic Agents in the Treatment of Neurobehavioral Deficits Following Traumatic Brain Injury.

S. L. Griffin, R. van Reekum, and C. Masanic (2003)
J Neuropsychiatry Clin Neurosci 15, 17-26
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

Donepezil and flight simulator performance: Effects on retention of complex skills.

J. A. Yesavage, M. S. Mumenthaler, J. L. Taylor, L. Friedman, R. O'Hara, J. Sheikh, J. Tinklenberg, and P. J. Whitehouse (2002)
Neurology 59, 123-125
 |  Abstract »  |  Full Text »  |  PDF »

beta -Amyloid Peptide Activates alpha 7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes.

K. T. Dineley, K. A. Bell, D. Bui, and J. D. Sweatt (2002)
J. Biol. Chem. 277, 25056-25061
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of Hippocampal CA1 Heterosynaptic Transformation and Spatial Memory by beta -Amyloid25-35.

M.-K. Sun and D. L. Alkon (2002)
J Neurophysiol 87, 2441-2449
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal Neurons.

J. M. Power and P. Sah (2002)
J. Neurosci. 22, 3454-3462
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis.

S. Boncristiano, M. E. Calhoun, P. H. Kelly, M. Pfeifer, L. Bondolfi, M. Stalder, A. L. Phinney, D. Abramowski, C. Sturchler-Pierrat, A. Enz, et al. (2002)
J. Neurosci. 22, 3234-3243
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine1A Receptor Agonist OPC-14523 (1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).

K. Tottori, M. Nakai, Y. Uwahodo, T. Miwa, S. Yamada, Y. Oshiro, T. Kikuchi, and C. A. Altar (2002)
J. Pharmacol. Exp. Ther. 301, 249-257
 |  Abstract »  |  Full Text »  |  PDF »

Complete Deletion of the Neurotrophin Receptor p75NTR Leads to Long-Lasting Increases in the Number of Basal Forebrain Cholinergic Neurons.

T. Naumann, E. Casademunt, E. Hollerbach, J. Hofmann, G. Dechant, M. Frotscher, and Y.-A. Barde (2002)
J. Neurosci. 22, 2409-2418
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal nicotinic acetylcholine receptors: involvement in Alzheimer's disease and schizophrenia..

D. S. Woodruff-Pak and T. J. Gould (2002)
Behav Cogn Neurosci Rev 1, 5-20
 |  Abstract »  |  PDF »

Aging Causes a Preferential Loss of Cholinergic Innervation of Characterized Neocortical Pyramidal Neurons.

M. A. Casu, T. Pan Wong, Y. De Koninck, A. Ribeiro-da-Silva, and A. C. Cuello (2002)
Cereb Cortex 12, 329-337
 |  Abstract »  |  Full Text »  |  PDF »

Organisation and functional role of the brain angiotensin system.

C. Llorens-Cortes and F. A. Mendelsohn (2002)
Journal of Renin-Angiotensin-Aldosterone System 3, S39-S48
 |  PDF »

Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacology.

S. N. Young (2002)
Can. Med. Assoc. J. 166, 205-209
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Behavioral Disturbances Associated with Dementia: Nursing Implications.

M. A. Boyd (2001)
Journal of the American Psychiatric Nurses Association 7, S14-S22
 |  Abstract »  |  PDF »

Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial.

K Rockwood, J Mintzer, L Truyen, T Wessel, and D Wilkinson (2001)
J. Neurol. Neurosurg. Psychiatry 71, 589-595
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?.

T. Ohnishi, H. Matsuda, T. Tabira, T. Asada, and M. Uno (2001)
AJNR Am. J. Neuroradiol. 22, 1680-1685
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Bis(7)-Tacrine on Spontaneous Synaptic Activity and on the Nicotinic ACh Receptor of Torpedo Electric Organ.

E. Ros, J. Aleu, I. Gomez De Aranda, C. Canti, Y.-P. Pang, J. Marsal, and C. Solsona (2001)
J Neurophysiol 86, 183-189
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Enhancement of Synaptic Efficacy, Spatial Learning, and Memory through Carbonic Anhydrase Activation in Rats.

M.-K. Sun and D. L. Alkon (2001)
J. Pharmacol. Exp. Ther. 297, 961-967
 |  Abstract »  |  Full Text »

Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients.

L. Han, J. McCusker, M. Cole, M. Abrahamowicz, F. Primeau, and M. Elie (2001)
Arch Intern Med 161, 1099-1105
 |  Abstract »  |  Full Text »  |  PDF »

Heterosynaptic Transformation of GABAergic Gating in the Hippocampus and Effects of Carbonic Anhydrase Inhibition.

M.-K. Sun, D. Dahl, and D. L. Alkon (2001)
J. Pharmacol. Exp. Ther. 296, 811-817
 |  Abstract »  |  Full Text »

Long-Lasting Cholinergic Modulation Underlies Rule Learning in Rats.

D. Saar, Y. Grossman, and E. Barkai (2001)
J. Neurosci. 21, 1385-1392
 |  Abstract »  |  Full Text »  |  PDF »

Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia.

K. L. Lanctôt, N. Herrmann, and P. Mazzotta (2001)
J Neuropsychiatry Clin Neurosci 13, 5-21
 |  Abstract »  |  Full Text »

Verbal and Visual Memory Improve After Choline Supplementation in Long-Term Total Parenteral Nutrition: A Pilot Study.

A. L. Buchman, M. Sohel, M. Brown, D. J. Jenden, C. Ahn, M. Roch, and T. L. Brawley (2001)
JPEN J Parenter Enteral Nutr 25, 30-35
 |  Abstract »  |  PDF »

Cholinergic Modulation of Excitatory Synaptic Transmission in the CA3 Area of the Hippocampus.

K. E. Vogt and W. G. Regehr (2001)
J. Neurosci. 21, 75-83
 |  Abstract »  |  Full Text »  |  PDF »

Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial.

G. K Wilcock, S. Lilienfeld, and E. Gaens (2000)
BMJ 321, 1445
 |  Abstract »  |  Full Text »

Cholinergic deficits contribute to behavioral disturbance in patients with dementia.

S. L. Minger, M. M. Esiri, B. McDonald, J. Keene, J. Carter, T. Hope, and P. T. Francis (2000)
Neurology 55, 1460-1467
 |  Abstract »  |  Full Text »  |  PDF »

The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease.

P. Tiraboschi, L. A. Hansen, M. Alford, E. Masliah, L. J. Thal, and J. Corey-Bloom (2000)
Neurology 55, 1278-1283
 |  Abstract »  |  Full Text »  |  PDF »

The corticofugal system for hearing: Recent progress.

N. Suga, E. Gao, Y. Zhang, X. Ma, and J. F. Olsen (2000)
PNAS 97, 11807-11814
 |  Abstract »  |  Full Text »  |  PDF »

Effects of the Selective M1 Muscarinic Receptor Antagonist Dicyclomine on Emotional Memory.

R. V. Fornari, K. M. Moreira, and M. G. M. Oliveira (2000)
Learn. Mem. 7, 287-292
 |  Abstract »  |  Full Text »

Experience-dependent plasticity in the auditory cortex and the inferior colliculus of bats: Role of the corticofugal system.

E. Gao and N. Suga (2000)
PNAS 97, 8081-8086
 |  Abstract »  |  Full Text »  |  PDF »

A 5-month, randomized, placebo-controlled trial of galantamine in AD.

P. N. Tariot, P. R. Solomon, J. C. Morris, P. Kershaw, S. Lilienfeld, and C. Ding (2000)
Neurology 54, 2269-2276
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice.

S. Capsoni, G. Ugolini, A. Comparini, F. Ruberti, N. Berardi, and A. Cattaneo (2000)
PNAS 97, 6826-6831
 |  Abstract »  |  Full Text »  |  PDF »

The Preclinical Pharmacological Profile of WAY-132983, a Potent M1 Preferring Agonist.

A. C. Bartolomeo, H. Morris, J. J. Buccafusco, N. Kille, S. Rosenzweig-Lipson, M. G. Husbands, A. L. Sabb, M. Abou-Gharbia, J. A. Moyer, and C. A. Boast (2000)
J. Pharmacol. Exp. Ther. 292, 584-596
 |  Abstract »  |  Full Text »

Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease.

P. Camps, B. Cusack, W. D. Mallender, R. E. Achab, J. Morral, D. Muñoz-Torrero, and T. L. Rosenberry (2000)
Mol. Pharmacol. 57, 409-417
 |  Abstract »  |  Full Text »

The M1 Muscarinic Agonist CI-1017 Facilitates Trace Eyeblink Conditioning in Aging Rabbits and Increases the Excitability of CA1 Pyramidal Neurons.

C. Weiss, A. R. Preston, M. M. Oh, R. D. Schwarz, D. Welty, and J. F. Disterhoft (2000)
J. Neurosci. 20, 783-790
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor (NGF) Augments Cortical and Hippocampal Cholinergic Functioning after p75NGF Receptor-Mediated Deafferentation But Impairs Inhibitory Avoidance and Induces Fear-Related Behaviors.

J. Winkler, G. A. Ramirez, L. J. Thal, and J. J. Waite (2000)
J. Neurosci. 20, 834-844
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal-Glial Interactions Mediated by Interleukin-1 Enhance Neuronal Acetylcholinesterase Activity and mRNA Expression.

Y. Li, L. Liu, J. Kang, J. G. Sheng, S. W. Barger, R. E. Mrak, and W. S. T. Griffin (2000)
J. Neurosci. 20, 149-155
 |  Abstract »  |  Full Text »  |  PDF »

Donepezil Therapy in Clinical Practice: A Randomized Crossover Study.

S. M. Greenberg, M. K. Tennis, L. B. Brown, T. Gomez-Isla, D. L. Hayden, D. A. Schoenfeld, K. L. Walsh, C. Corwin, K. R. Daffner, P. Friedman, et al. (2000)
Arch Neurol 57, 94-99
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Markers in Alzheimer Disease.

R. T. Bartus, D. F. Emerich, K. L. Davis, D. Marin, D. P. Purohit, D. Perl, M. Lantz, G. Austin, and V. Haroutunian (1999)
JAMA 282, 2208-2209
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Absorption, Distribution, Metabolism, and Excretion of Donepezil (Aricept) after a Single Oral Administration to Rat.

K. Matsui, M. Mishima, Y. Nagai, T. Yuzuriha, and T. Yoshimura (1999)
Drug Metab. Dispos. 27, 1406-1414
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Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy.

D. E. Smith, J. Roberts, F. H. Gage, and M. H. Tuszynski (1999)
PNAS 96, 10893-10898
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Brain Choline Acetyltransferase and Mental Function in Alzheimer Disease.

D. S. Baskin, J. L. Browning, F. J. Pirozzolo, S. Korporaal, J. A. Baskin, and S. H. Appel (1999)
Arch Neurol 56, 1121-1123
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Challenging the Cholinergic Hypothesis in Alzheimer Disease.

P. Davies (1999)
JAMA 281, 1433-1434
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Metrifonate Increases Neuronal Excitability in CA1 Pyramidal Neurons from Both Young and Aging Rabbit Hippocampus.

M. M. Oh, J. M. Power, L. T. Thompson, P. L. Moriearty, and J. F. Disterhoft (1999)
J. Neurosci. 19, 1814-1823
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The cholinergic hypothesis of Alzheimer's disease: a review of progress.

P. T Francis, A. M Palmer, M. Snape, and G. K Wilcock (1999)
J. Neurol. Neurosurg. Psychiatry 66, 137-147
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Improving Effects of Huperzine A on Spatial Working Memory in Aged Monkeys and Young Adult Monkeys with Experimental Cognitive Impairment.

J. W. Ye, J. X. Cai, L. M. Wang, and X. C. Tang (1999)
J. Pharmacol. Exp. Ther. 288, 814-819
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