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Science 23 July 1982:
Vol. 217. no. 4557, pp. 369 - 371
DOI: 10.1126/science.6124040
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Articles

Science, Vol 217, Issue 4557, 369-371
Copyright © 1982 by American Association for the Advancement of Science

articles

Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani

RD Pearson, AA Manian, JL Harcus, D Hall, and EL Hewlett

Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.


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Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in Experimental Murine Cutaneous Leishmaniasis and Visceral Leishmaniasis.
H. M. Al-Abdely, J. R. Graybill, R. Bocanegra, L. Najvar, E. Montalbo, S. L. Regen, and P. C. Melby (1998)
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Cytoskeletal Association Is Important for Differential Targeting of Glucose Transporter Isoforms in Leishmania.
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Antiprotozoal activity of tricyclic compounds.
E. Hewlett, R. Pearson, D Zilberstein, and D. Dwyer (1985)
Science 230, 1063-1064
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