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Science 23 July 1982:
Vol. 217. no. 4557, pp. 367 - 369
DOI: 10.1126/science.6283635
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Articles

Science, Vol 217, Issue 4557, 367-369
Copyright © 1982 by American Association for the Advancement of Science

articles

Immunotherapy of metastases enhances subsequent chemotherapy

MG Hanna Jr and ME Key

In many multimodal therapies of cancer, postsurgical chemotherapy is administered before immunotherapy for treatment of micrometastatic disease. This sequence may not be the most efficacious. Experiments in which strain 2 guinea pigs bearing syngeneic L10 hepatocarcinomas were given immunotherapy showed that infiltrating immune effector cells not only were tumoricidal but disrupted the characteristically compact structure of metastatic foci. When cytotoxic drugs were administered at the peak of this inflammatory response, the survival rate of the guinea pigs increased significantly. We conclude that postsurgical immunotherapy can enhance the effect of cytotoxic drugs administered subsequently.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adjuvant Active Specific Immunotherapy for Stage II and III Colon Cancer With an Autologous Tumor Cell Vaccine: Eastern Cooperative Oncology Group Study E5283.
J. E. Harris, L. Ryan, H. C. Hoover Jr, R. K. Stuart, M. M. Oken, A. B. Benson III, E. Mansour, D. G. Haller, J. Manola, and M. G. Hanna Jr (2000)
J. Clin. Oncol. 18, 148
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Science. ISSN 0036-8075 (print), 1095-9203 (online)