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Science 23 July 1982:
Vol. 217. no. 4557, pp. 316 - 324
DOI: 10.1126/science.6283634

Articles

Science, Vol 217, Issue 4557, 316-324
Copyright © 1982 by American Association for the Advancement of Science


articles

Transcriptional control signals of a eukaryotic protein-coding gene

SL McKnight and R Kingsbury

Transcriptional control signals of a model eukaryotic protein-coding gene have been identified by a new procedure of in vitro mutagenesis. This method allows small clusters of nucleotide residues to be substituted in a site-directed manner without causing the addition or deletion of other sequences. Transcription assays of a systematic series of these clustered point mutants have led to the identification of three distinct control signals located within the 105-nucleotide residues immediately upstream from the point where transcription begins.


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S H Kim, M K Darby, K E Joho, and D D Brown (1990)
Genes & Dev. 4, 1602-1610
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Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.
R. O'Brien, P. Lucas, C. Forest, M. Magnuson, and D. Granner (1990)
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E Martinez-Salas, E Linney, J Hassell, and M L DePamphilis (1989)
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J C Mordacq and D I Linzer (1989)
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L Wu and A Berk (1988)
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The immunoglobulin octanucleotide: independent activity and selective interaction with enhancers.
T. Parslow, S. Jones, B Bond, and K. Yamamoto (1987)
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A genetic approach to promoter recognition during trans induction of viral gene expression.
D. Coen, S. Weinheimer, and S. McKnight (1986)
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Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.
K. Jones, J. Kadonaga, P. Luciw, and R Tjian (1986)
Science 232, 755-759
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Fine structure genetic analysis of a beta-globin promoter.
R. Myers, K Tilly, and T Maniatis (1986)
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In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
H Scholer, A Haslinger, A Heguy, H Holtgreve, and M Karin (1986)
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Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements.
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D Botstein and D Shortle (1985)
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