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Science 16 July 1982:
Vol. 217. no. 4556, pp. 261 - 263
DOI: 10.1126/science.7089564
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Articles

Science, Vol 217, Issue 4556, 261-263
Copyright © 1982 by American Association for the Advancement of Science

articles

An enzymatic system for removing heparin in extracorporeal therapy

R Langer, RJ Linhardt, S Hoffberg, AK Larsen, CL Cooney, D Tapper, and M Klein

The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Relative Neutralization of the Biological Actions of Sulfaminoheparosans (K5 Derivatives) and Heparins by Protamine Sulfate.
J. Maddineni, D. A. Hoppensteadt, U. Cornelli, M. Manoni, and J. Fareed (2007)
Clinical and Applied Thrombosis/Hemostasis 13, 52-64
   Abstract »    PDF »
Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application.
G. A. Ameer, G. Barabino, R. Sasisekharan, W. Harmon, C. L. Cooney, and R. Langer (1999)
PNAS 96, 2350-2355
   Abstract »    Full Text »    PDF »
Heparinase I from Flavobacterium heparinum.
R. Sasisekharan, G. Venkataraman, R. Godavarti, S. Ernst, C. L. Cooney, and R. Langer (1996)
J. Biol. Chem. 271, 3124-3131
   Abstract »    Full Text »    PDF »
Arginase Immobilization on Poly(hydroxyethyl acrylate) Matrix Beads.
F.M. Veronese, E. Boccu, P. Caliceti, S. Lora, M. Carenza, and G. Palma (1989)
Journal of Bioactive and Compatible Polymers 4, 42-50
   Abstract »    PDF »
Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice.
A Lavin, C Sung, A. Klibanov, and R Langer (1985)
Science 230, 543-545
   Abstract »    PDF »
Continuous Arteriovenous Hemofiltration: A Report of Six Months' Experience.
A. A. KAPLAN, R. E. LONGNECKER, and V. W. FOLKERT (1984)
Ann Intern Med 100, 358-367
   Abstract »    PDF »
Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone.
J Folkman, R Langer, R. Linhardt, C Haudenschild, and S Taylor (1983)
Science 221, 719-725
   Abstract »    PDF »
Immobilized Enzymes and Cells as Practical Catalysts.
A. M. Klibanov (1983)
Science 219, 722-727
   Abstract »    PDF »
Bioreactors: Design and Operation.
C. L. Cooney (1983)
Science 219, 728-733
   Abstract »    PDF »


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