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Science 16 July 1982:
Vol. 217. no. 4556, pp. 248 - 250
DOI: 10.1126/science.7089561
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Articles

Science, Vol 217, Issue 4556, 248-250
Copyright © 1982 by American Association for the Advancement of Science

articles

The anticancer agent adriamycin can be actively cytotoxic without entering cells

TR Triton and G Yee

The antineoplastic agent adriamycin was coupled to an insoluble agarose support. This material was actively cytotoxic to L1210 cells in culture under conditions in which no free adriamycin could enter the cell. It is concluded that an agent whose principal target was previously thought to be DNA can exert its cytotoxic action solely by interaction at the cell surface.


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Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II.
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