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Science 9 July 1982:
Vol. 217. no. 4555, pp. 162 - 164
DOI: 10.1126/science.7089550
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Articles

Science, Vol 217, Issue 4555, 162-164
Copyright © 1982 by American Association for the Advancement of Science

articles

Neonatal treatment with antiserum to prolactin lowers blood pressure in rats

DE Mills, MT Buckman, and GT Peake

Prolactin administration reportedly increases blood pressure in rats and rabbits. To study the effects of prolactin deficiency on blood pressure, rats were given saline, normal rabbit serum, or rabbit antiserum to rat prolactin on postnatal days 2 to 5. Both males and females given antiserum had significantly lower blood pressure at 14 weeks than rats given saline or normal rabbit serum. Blood pressure differences between females given antiserum and females given saline disappeared during and following pregnancy. The antiserum also lowered the concentration of prolactin in plasma 49 percent in males and decreased the prolactin response to ether stress in both sexes. These results suggest that endogenous prolactin is involved in blood pressure regulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat.
M. S. Landa, S. I. Garcia, M. L. Schuman, A. Burgueno, A. L. Alvarez, F. E. Saravia, C. Gemma, and C. J. Pirola (2007)
Am J Physiol Endocrinol Metab 292, E1388-E1394
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