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ArticlesCopyright © 1982 by American Association for the Advancement of Science
Prevention of Allograft Rejection by Immunization with Donor Blood Depleted of Ia-Bearing Cells
Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)