Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 July 1982:
Vol. 217. no. 4554, pp. 70 - 72
DOI: 10.1126/science.6979780
Prev | Table of Contents | Next

Articles

Science, Vol 217, Issue 4554, 70-72
Copyright © 1982 by American Association for the Advancement of Science

articles

Muscular contraction: kinetics of crossbridge attachment studied by high-frequency stiffness measurements

G Cecchi, PJ Griffiths, and S Taylor

Instantaneous stiffness of frog skeletal muscle, an indication of the proportion of attached crossbridges, was determined drug the tetanus rise and after a step length change imposed during the tetanus plateau. During the onset of contraction as well as after a step, the ratio of stiffness to force differed from that determined during the tetanus plateau. The data after a step are predicted by the Huxley-Simmons model of muscular contraction, but the results during the rise suggest that a long-lived state may exist between crossbridge attachment and force generation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural changes in the myosin filament and cross-bridges during active force development in single intact frog muscle fibres: stiffness and X-ray diffraction measurements.
E. Brunello, P. Bianco, G. Piazzesi, M. Linari, M. Reconditi, P. Panine, T. Narayanan, W.I. Helsby, M. Irving, and V. Lombardi (2006)
J. Physiol. 577, 971-984
   Abstract »    Full Text »    PDF »
Crossbridge properties investigated by fast ramp stretching of activated frog muscle fibres.
M. A. Bagni, G. Cecchi, and B. Colombini (2005)
J. Physiol. 565, 261-268
   Abstract »    Full Text »    PDF »
Non-cross-bridge calcium-dependent stiffness in frog muscle fibers.
M. A. Bagni, B. Colombini, P. Geiger, R. Berlinguer Palmini, and G. Cecchi (2004)
Am J Physiol Cell Physiol 286, C1353-C1357
   Abstract »    Full Text »    PDF »
Series-to-parallel transition in the filament lattice of airway smooth muscle.
C. Y. Seow, V. R. Pratusevich, and L. E. Ford (2000)
J Appl Physiol 89, 869-876
   Abstract »    Full Text »    PDF »
Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres.
G. Piazzesi, M. Reconditi, I. Dobbie, M. Linari, P. Boesecke, O. Diat, M. Irving, and V. Lombardi (1999)
J. Physiol. 514, 305-312
   Abstract »    Full Text »    PDF »
Activation of smooth muscle contraction: relation between myosin phosphorylation and stiffness.
K. Kamm and J. Stull (1986)
Science 232, 80-82
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)