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Science 25 June 1982:
Vol. 216. no. 4553, pp. 1423 - 1425
DOI: 10.1126/science.6124036
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Articles

Science, Vol 216, Issue 4553, 1423-1425
Copyright © 1982 by American Association for the Advancement of Science

articles

Schizophrenia: dopamine beta-hydroxylase activity and treatment response

DE Sternberg, DP VanKammen, P Lerner, and WE Bunney

Cerebrospinal fluid levels of dopamine beta-hydroxylase, found to be relatively constant over time in individual patients, were significantly lower in schizophrenic patients who became nonpsychotic during neuroleptic treatment than in those who remained psychotic. Dopamine beta-hydroxylase activity may delineate a subgroup of patients who have a dopamine-sensitive brain disorder.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Norepinephrine in Acute Exacerbations of Chronic Schizophrenia: Negative Symptoms Revisited.
D. P. van Kammen, J. Peters, J. Yao, W. B. van Kammen, T. Neylan, D. Shaw, and M. Linnoila (1990)
Arch Gen Psychiatry 47, 161-168
   Abstract »    PDF »
Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients.
D Pickar, R Labarca, M Linnoila, A Roy, D Hommer, D Everett, and S. Paul (1984)
Science 225, 954-957
   Abstract »    PDF »
Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila (1983)
Science 220, 974-977
   Abstract »    PDF »


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