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Science 25 June 1982:
Vol. 216. no. 4553, pp. 1421 - 1423
DOI: 10.1126/science.6283631
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Articles

Science, Vol 216, Issue 4553, 1421-1423
Copyright © 1982 by American Association for the Advancement of Science

articles

Nucleotide sequence of the transforming gene of avian myeloblastosis virus

KE Rushlow, JA Lautenberger, TS Papas, MA Baluda, B Perbal, JG Chirikjian, and EP Reddy

Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.


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