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Science 25 June 1982:
Vol. 216. no. 4553, pp. 1419 - 1421
DOI: 10.1126/science.7089530
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Articles
Science, Vol 216, Issue 4553, 1419-1421
Copyright © 1982 by American Association for the Advancement of Science
In vivo activation of zoxazolamine metabolism by flavone
JM Lasker,
M-T Huang,
and
AH Conney
The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate several-fold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a zenobiotic that is an activator of hepatic microsomal.
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